Washington: The first genetic mutation ever associated with a mysterious and potentially devastating form of heart disease that affects women in the final weeks of pregnancy or the first few months after delivery have been identified by researchers at the Intermountain Medical Center Heart Institute. The disease, peripartum cardiomyopathy (PPCM), weakens a woman’s heart so that it no longer pumps blood efficiently. The cause of PPCM has been unknown. “This is an important breakthrough,” said Benjamin Horne, director of cardiovascular and genetic epidemiology at Intermountain Medical Center and lead researcher for the study. “Until now, no one has identified a genetic link to the disease. This gives us and other researchers a roadmap that tells us where to look in the human genome for more information about the disease,” said Horne.
“It turns out that the mutation on chromosome 12 is located near a gene that is a good candidate for pregnancy-related cardiomyopathy,” said Horne. “That gene has been shown to be involved in regulating blood pressure and muscle contraction in the uterus and the heart,” he added. The study has been published in the online edition of Circulation: Cardiovascular Genetics. ANI
Firing across Pak-India border kills two
Ranchi: Violent clashes between JMM, BJP workers
SC refuses to postpone UPSC prelims
Jaipur: Air India flight makes emergency landing due to technical fault