Washington: We all know that exercise comes with metabolic and cardiovascular benefits, but little is understood about how physical activity influences the heart itself. Now, a new study offers some of the first molecular-level insights.
The researchers found changes in 175 transcription factors in exercised mice and 96 in mice whose aortas were constricted. Importantly, the changes showed little overlap between the two animal models. For instance, the researchers said, 13 percent of the genes with differential expression following exercise have known or suggested roles in cell proliferation compared to less than one percent of those that changed with the surgery. Studies in animals and cell culture also showed that the decline in C/EPBb leads to changes that appear to be consistent with those that follow endurance exercise, including an increase in heart muscle size and proliferation. Those mice with lower C/EPBb levels also were resistant to heart failure. That finding is key given that there is little prior evidence showing that the increase in heart size with exercise has direct benefits, said the researchers. The study was published in the journal Cell, a Cell Press publication. ANI
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