Washington: Scientists from Carnegie Mellon University have identified a potential therapeutic target for controlling viral infection. Within a virus’s tiny exterior is a store of energy waiting to be unleashed. When the virus encounters a host cell, this pent-up energy is released, propelling the viral DNA into the cell and turning it into a virus factory.
Evilevitch and his colleagues from Lund University in Sweden, where Evilevitch was previously employed, and the University de Lyon in France used an experimental technique known as isothermal titration calorimetric (ITC) to directly measure the heat, and thus the thermal energy, released during viral genome ejection. "Understanding the energy profile for viral genome release provides information on how to interfere with the process,” Evilevitch said. For example, developing ways to decrease the internal energy in viruses could prevent viruses from ejecting their genome and prevent infection," he added. ANI
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