Washington: Obese women can reduce their increased risk of endometrial disease if they take vitamin D supplements, a new animal study has revealed.
Therefore, in this study, researchers keyed in on a potential link between weight, a known endometrial cancer risk factor, and vitamin D, a potential reducer of risk in many cancers. They used the best animal model available to look at endometrial cancer - the PTEN knock-out mice.The research team, which included investigators from the National Cancer Institute, Northwestern University, Wake Forest University School of Medicine, and Walter Reed Hospital, divided their PTEN- mice into four groups.One group was fed a normal diet and one received a normal diet with supplements of vitamin D. Another group was fed a high-fat diet, and the fourth group received a high fat diet plus vitamin D.They found that in the mice fed a normal diet, the use of vitamin D had no effect on the development of endometrial cancer - about 60 percent of mice in both groups developed the cancer.And 67 percent of mice that became obese from a high fat diet developed the cancer, while only 25 percent of obese mice that also received vitamin D developed endometrial cancer.The findings were published in the Cancer Prevention Research. ANI
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