Maternal obesity ups risk of frequent wheezing in offspring
Washington: Women who are obese during pregnancy put their offspring at four times the risk to have frequent wheezing, a symptom associated with susceptibility to asthma during infancy that manifests as sharp, whistling sounds when breathing, a new study has warned.
During an asthma attack, the muscles surrounding the airways tense up and their lining becomes inflamed. The passage of air is then reduced. One of the symptoms is wheezing which as a general rule begins subtly and can then worsen during the night or the first few hours of the day when breathing in cold air or even during exercise.
The study by the Centre for Research in Environmental Epidemiology confirms that on average the risk of wheezing during the first 14 months of life is four times greater in the children of mothers with obesity compared to the children of mothers with a normal weight.
"We are basing this on the assumption that obesity in mothers can be a potential intergenerational risk factor for asthma," as explained to SINC by Stefano Guerra, lead author of the study. "Our proposal was to determine whether maternal obesity is associated with a greater risk of early wheezing phenotypes in children."
Therefore, the experts analysed the data of 1,107 pairs of mother and child from a Spanish study on infancy and environment (INMA project). The results confirmed the association between maternal obesity and wheezing regardless of the weight of the child and other factors such as the education of the mother, her age, whether she is a smoker, etc.
"The independent relationship of obesity before pregnancy with the increased risk of frequent wheezing in children adds more evidence to the effects of foetal exposure and its consequences on asthma-related phenotypes," states Guerra, suggesting "possible preventative benefits of loosing excess weight."
The study has been published in the Paediatric and Perinatal Epidemiology.