Antibiotic resistance genes found in 14th century human poop
London: French scientists have discovered antibiotic resistance genes in fossilised human feces from 14th century, long before antibiotics were used in medicine.
Analysing the fecal sample from Belgium for its viral components, researchers found a range of phages - viruses that infect bacteria.
The viruses in the fecal sample are phages rather than infecting eukaryotic organisms such as animals, plants, and fungi.
Most of the viral sequences the researchers found in the ancient coprolite (fossil fecal sample) were related to viruses currently known to infect bacteria commonly found in stools (and hence, in the human gastrointestinal tract).
These included both bacteria that live harmlessly, and even helpfully in the human gut, and human pathogens, said corresponding author Christelle Desnues of Aix Marseille Universite in France.
The communities of phage within the coprolite were different, taxonomically, from those seen within modern human fecal samples, but the functions they carry out appear to be conserved, said Desnues.
The finding reinforces the hypothesis that the viral community plays a fundamental role within the human gastrointestinal tract, and one which remains unchanged after centuries, even while the human diet and other human conditions have been changing, researchers said.
Over the last five years, considerable evidence has emerged that bacteria inhabiting the gut play an important role in maintaining human health, for example, as part of the human metabolic system, said Desnues.
Her own research suggests that bacteriophage infecting the gut bacteria may help maintain these bacteria. Among the genes found in the phage are antibiotic resistance genes and genes for resistance to toxic compounds.
Both toxins and antibiotics are common in nature, and Desnues suggests that the resistance genes may simply be protecting the gut bacteria from them.
"Our evidence demonstrates that bacteriophages represent an ancient reservoir of resistance genes and that this dates at least as far back as the Middle Ages," said Desnues.
"We were interested in viruses because these are 100 times more abundant than human cells in our bodies, but their diversity is still largely unexplored," said Desnues.
The study was published in the journal Applied and Environmental Microbiology.
More from India
More from World
More from Sports
More from Entertaiment
- Panel discussion over PM Modi's willingness to engage in direct dialogue with Pak
- PM Modi slams Pakistan govt during his speech in Kozhikode
- DNA: US army's joint exercise with Indian Army and their consolation on Uri attack
- DNA: Analysis of Indus water treaty between India and Pakistan
- Panel discussion over PM Modi's willingness to engage in direct dialogue with Pak - Part II
- SHOCKING VIDEO: This man was trying to take selfie with python - You won't believe what happened next!
- Donald Trump praises Hindu community's contributions to US
- Uri effect? India, Afghanistan bypass Pak to set up exclusive air corridor
- Reliance Jio impact: Vodafone offers 10 GB data at 1 GB rate
- Govt calls meet on Indus Water Treaty; Water Resources Ministry, MEA to brief PM Modi