The gunmen attacked ANP leader Malik Yaqoob's car at Nowshera in the North West Frontier Province.
Yaqoob and his bodyguard were killed on the spot, police said. No group claimed responsibility for the attack.
Over the past year, the Taliban have frequently targeted leaders and workers of the ANP, which rules the NWFP and is part of the ruling coalition at the centre.
The ANP has strongly backed the military operations against the Taliban and ruled out the possibility of holding talks with militants.
Islamabad: A leader of the Awami National Party and his bodyguard were shot dead by unidentified gunmen in northwest Pakistan on Monday, police said.
First Published: Monday, November 16, 2009, 15:31