PML-N leader Aziz Imrani was shot dead when the gunmen ambushed his vehicle on Karkh Road in Khuzdar district, police said.
Three of his guards were critically injured in the attack.
Police cordoned off the site of the attack and took the injured guards to a nearby hospital.
No group claimed responsibility for the attack.
Islamabad: A leader of the main opposition PML-N was killed and three of his guards were injured in an attack by unidentified gunmen in Pakistan's southwestern Balochistan province on Saturday.
First Published: Saturday, March 06, 2010, 16:21