The two gunmen entered the restaurant Saturday, walked to the table where the four young men were eating and opened fire.
Two of the victims were pronounced dead at the scene, while the other two died at a hospital in the second-largest city in Honduras.
The pizzeria is in the Las Palmas district near the San Pedro Sula penitentiary.
The crime wave in Honduras has left an average of 20 people dead a day, according to the Observatory of Violence of the National Autonomous University, which reported that 10,411 violent deaths, of which 7,172 were murders, occurred in the Central American country in 2012.
Honduras had a homicide rate of 85.5 per 100,000 inhabitants last year, with an average of 598 homicides monthly and 20 kilings daily.
Tegucigalpa: Gunmen killed four people at a pizzeria in San Pedro Sula, a city in northern Honduras, the National Police said.
First Published: Monday, March 04, 2013, 11:45