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New approach to restore Penicillin`s combating power

A new approach may restore Penicillin`s combat effectiveness, even against `superbugs`, by pairing the drug with a protective polymer, scientists say.



Washington: A new approach may restore Penicillin`s combat effectiveness, even against `superbugs`, by pairing the drug with a protective polymer, scientists say.

"Penicillin, one of the scientific marvels of the 20th century, is currently losing a lot of battles it once won against bacterial infections," researchers said.

Now, scientists at the University of South Carolina have reported a new approach to restoring its combat effectiveness, even against so-called superbugs.

Bacteria have been chipping away at the power of the penicillin family of drugs since their first wide-scale use as antibiotics in the 1940s, researchers said.

A cyclic four-membered amide ring termed a beta-lactam is a common structural element of the penicillins, their synthetic and semi-synthetic derivatives.

Physicians heavily use the many versions of beta-lactam antibiotics to fight bacterial infections, and many have been retired because they`re no longer effective against the defences bacteria have evolved in response.

One of the most effective bacterial defences is an enzyme called beta-lactamase, which chews up the beta-lactam structure, researchers said.

Some bacteria, such as MRSA, have developed the ability to biosynthesise and release beta-lactamase when needed.

The new approach by Carolina`s Chuanbing Tang pairs the drug with a protective polymer developed in his chemistry laboratory.

In lab tests, graduate student Jiuyang Zhang prepared a cobaltocenium metallopolymer that greatly slowed the destructiveness of beta-lactamase on a model beta-lactam molecule (nitrocefin).

The interdisciplinary team also showed that the antimicrobial effectiveness of the four beta-lactams studied in detail was enhanced by the polymer.

The enhancement was modest against two strains, but very pronounced with the hospital-associated strain of MRSA (HA-MRSA).

The metallopolymer by itself even demonstrated antimicrobial properties, lysing bacterial cells while leaving human red blood cells unaffected.
By a variety of measures, the polymer was found to be nontoxic to human cells in laboratory tests.
The research was published in the Journal of the American Chemical Society.

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