Cairo: Protesters in Egypt violated an overnight curfew in towns along the Suez Canal, vandalising police stations and defying the emergency rule imposed by Islamist President Mohamed Mursi.
Over the past few days, at least 52 people have died in clashes that started on the eve of the second anniversary of the 2011 revolt that brought down the then president Hosni Mubarak.
Police said two people were killed in overnight fighting in Port Said, as per a leading news agency.
Opponents of President Mursi rejected a call for talks on Monday aimed at ending the violence.
Instead, huge crowds of protesters took to the streets in Cairo, Alexandria and in the three Suez Canal cities - Port Said, Ismailia and Suez - where Mursi imposed emergency rule and a curfew on Sunday.
"Down, down with Mohamed Mursi! Down, down with the state of emergency!" crowds shouted in Ismailia. In Cairo, flames lit up the night sky as protesters set police vehicles ablaze.
In Port Said, men attacked police stations after dark. A security source said some police and troops were injured. A medical source said two men were killed and 12 injured in the clashes, including 10 with gunshot wounds.
"The people want to bring down the regime," crowds chanted in Alexandria. "Leave means go, and don`t say no!"
The demonstrators accuse Mubarak`s successor Mursi of betraying the two-year-old revolution. Mursi and his supporters accuse the protesters of seeking to overthrow Egypt`s first ever democratically elected leader through undemocratic means.
Since Mubarak was toppled, Islamists have won two referendums, two Parliamentary Elections and a Presidential vote. But that legitimacy has been challenged by an opposition that accuses Mursi of imposing a new form of authoritarianism, and punctuated by repeated waves of unrest that have prevented a return to stability in the most populous Arab state.
(With Agency inputs)