London: England striker Daniel Sturridge has been ruled out of his side`s opening Euro 2016 qualifier against Switzerland next week.
Sturridge sustained a thigh injury during a training session with Roy Hodgson`s squad at their St George`s Park base on Friday.
The Liverpool star was sent for a scan and it was decided he would not be able to recover in time to feature against the Swiss in Basel on Monday.
"Daniel Sturridge picked up an injury on his thigh in training," an FA spokesman said.
"He has had a scan and will now return to Liverpool FC for treatment. He will play no part in the forthcoming Switzerland match."
Sturridge`s absence is a major blow to Hodgson as he was one of England`s better performers in the lacklustre 1-0 friendly win over Norway at Wembley on Wednesday.
Hodgson has not called up a replacement for Sturridge as he considers who will partner captain Wayne Rooney in attack in the most difficult of his side`s group stage fixtures.
Arsenal`s new signing Danny Welbeck is the most likely candidate, with Liverpool targetman Rickie Lambert another option for Hodgson if he wishes to play with two strikers.
There was another worrying sign for Hodgson as Chelsea defender Gary Cahill sat out training on Friday with an ankle complaint, although he is expected to return in time to feature in the Group E opener.
The England manager is already having to take an inexperienced squad to St Jakob-Park, with the international retirements of Steven Gerrard, Frank Lampard and Ashley Cole compounded by a lengthy injury list which includes Theo Walcott, Adam Lallana, Ross Barkley, Michael Carrick, Andy Carroll, Kyle Walker, Glen Johnson, Luke Shaw and Chris Smalling.
England came in for plenty of criticism for their showing against Norway, their first match after a dismal World Cup exit at the group stages, and Cahill conceded it would make a dynamic performance against Switzerland to start restoring the nation`s pride in the team.
"It`s disappointing, but expected from what happened in the summer," said Cahill.
"We`ve got a huge game on Monday and we know it`s going to be very, very tough. It`s a chance for us to bounce back in a game which really matters.
"It`s certainly one of the hardest games for us in the group. It`s a great opportunity for us to go and bounce back from the summer."
The Chelsea defender said fans had to have patience with a "very young squad" as they found their feet at international level.
"It`s tough to come into an England team, never mind where there is so called doom and gloom out there. The quality is certainly here," he added.
With Lampard and Gerrard retired, it was Arsenal`s Jack Wilshere and Liverpool`s Jordan Henderson who anchored England`s midfield against Norway.
Neither was especially impressive, but Wilshere is confident they can grow into a dominant partnership after playing with Henderson in the lower international age groups.
"I played with Jordan for a few years, you know, at under-21 level. I`ve always worked well with him. He`s a great player. He`s so fit, you`ve seen that for Liverpool. He can win challenges, he gets up to the ball and on the ball he`s got a lot of quality," Wilshere said.
"Obviously it`s disappointing when Steven and Frank retired, they were massive players for England, great ambassadors and that is the level me and Jordan have got to get to. We`re confident."