London: Manchester United will have to subdue another potential giant-killer after the 11-time FA Cup winners were handed a fourth round trip to League Two minnows Cambridge United in Monday`s draw.
Louis van Gaal`s team were paired with the lowest ranked team left in the Cup and will head to the tiny Abbey Stadium on the weekend of January 24-25.
A total of 79 league places separate Richard Money`s side with van Gaal`s star-studded line-up, who were able to avoid an embarrassing third round defeat at League One outfit Yeovil on Sunday as they cruised to a 2-0 win.
Holders Arsenal, 2-0 winners against last season`s beaten finalists Hull in the third round on Sunday, will also be hoping to avoid an upset when they travel to Championship team Brighton.
Manchester City host Championship promotion contenders Middlesbrough after coming from behind to win 2-1 against Sheffield Wednesday, another second tier team, on Sunday.
Premier League leaders Chelsea could face a feisty London derby against Millwall at Stamford Bridge if the Lions come through their replay with Bradford City.
Jose Mourinho`s men will be heavy favourites to advance whether they face Championship strugglers Millwall or League One promotion chasers Bradford, although the Lions knocked Chelsea out of the Cup in 1995 and 1985.
Sheffield United`s reward for their shock 3-0 win over QPR on Sunday is a trip to fellow third tier side Preston.
Draw for the fourth round of the English FA Cup made on Monday:
Southampton/Ipswich v Crystal Palace
Cambridge United v Manchester United
Blackburn v Swansea
Chelsea v Millwall/Bradford
Derby v Scunthorpe/Chesterfield
Preston v Sheffield United
Birmingham v West Brom
Aston Villa v Bournemouth
Cardiff v Reading
AFC Wimbledon/Liverpool v Bolton
Burnley/Tottenham v Leicester
Brighton v Arsenal
Rochdale v Stoke
Sunderland v Fulham/Wolves
Doncaster/Bristol City v Everton/West Ham
Manchester City v Middlesbrough
Ties to be played across the weekend beginning January 24.