Tottenham will face north London enemies Arsenal and Aston Villa will take on bitter rivals Birmingham in a pair of League Cup third round derby showdowns.
Mauricio Pochettino`s Tottenham were paired against Arsene Wenger`s Gunners in Tuesday`s draw.
Tottenham, who were beaten in last year`s final by Chelsea, will host the tie of the round at White Hart Lane in September.
It will be the first north London derby of the season.
There will be more derby intrigue when Villa clash with Championship side Birmingham for the first time since January 2011.
Birmingham are unbeaten in the last three meetings with Villa, including a League Cup tie in 2010.
Holders Chelsea travel to third tier Walsall, while Liverpool host fourth tier Carlisle.
Manchester United face Championship side Ipswich at Old Trafford and Manchester City travel to Sunderland.English League Cup draw made on Tuesday:
Middlesbrough v Wolves
Norwich v West Brom
Hull v Swansea
Leicester v West Ham
Aston Villa v Birmingham
Tottenham v Arsenal
Manchester United v Ipswich
Liverpool v Carlisle
Crystal Palace v Charlton
Fulham v Stoke
Sunderland v Manchester City
Newcastle v Sheffield Wednesday
Reading v Barnsley or Everton
Preston v Bournemouth
Walsall v Chelsea
Milton Keynes Dons v Southampton
Ties to be played in the week commencing September 21.