Coach Unai Emery said Sevilla will look for inspiration from their Europa League triumph two years ago when they seek to belie their poor La Liga form against Juventus in their Champions League group D clash on Wednesday.
Emery has fond memories of Juventus Stadium, having steered his side to the first of two consecutive Europa League triumphs in 2014 when they beat Benfica in a penalty shoot-out.
But the La Liga side are in a transition phase following the departure of key players during the summer, and have been hit hard recently with injury.
Sevilla`s form in the Spanish top flight appears at odds with what will be required to beat Juventus in Turin on Wednesday.
Emery`s men only moved up to fifth from bottom at the weekend after claiming their first win of the season.
The only positive for the visitors is that Juve, who have slumped to 15th place in Serie A, are in similar straits.
With Beto, Adil Rami, Daniel Carrico, Nico Pareja, Ever Banega, Gael Kakuta and Fernando Llorente all missing out through injury, Emery admitted his first team choices will be limited.
But the Spaniard is counting on the 11 players he does choose.
"After winning the Europa League here, we`re back for the Champions League which in football terms is the best event in the world," said Emery.
"We`re really motivated being back here. I will pick the best 11 players I have and hopefully they will go out and capitalise on the experience of being here."
Sevilla, who defended their Europa League title with a 3-2 triumph over Dnipro in Warsaw last season, opened their group campaign with a 3-0 win at home against Borussia Moenchengladbach.
Juventus stunned Manchester City 2-1, meaning both sides find themselves in the peculiar situation of winning in Europe while struggling at domestic level.
Juventus have several key players out injured, with striker Mario Mandzukic (thigh) joining a casualty list that already includes Claudio Marchisio.
On Tuesday, Swiss wingback/defender Stephan Lichsteiner was also ruled out, as was Martin Caceres -- although the Uruguayan was suspended by the club for crashing his Ferrari while driving under the influence.
Sevilla defender Grzegorz Krychowiak said: "Both sides started the season badly. Juve are a great side with top players but we have a lot of belief in ourselves and I`m sure both will play well."
Asked if Sevilla would be looking to play for a draw, Krychowiak said: "No, we always play to win."
Emery, meanwhile, suggested that when it comes to the Champions League, the influence of domestic form goes out the window.
"Juventus showed they can beat Manchester City, away from home when City were playing well," said Emery.
"They have a great side full of top quality players."