Australian champion Simon Gerrans did not start the 17th stage of the Tour de France on Wednesday.
The 34-year-old Orica GreenEDGE rider had been suffering since crashing on the first stage more than two weeks ago.
"Obviously it`s disappointing not to complete the Tour de France and make it to Paris," said the winner of April`s Liege-Bastogne-Liege.
"But with the injuries I have from stage one I think the best decision is actually to stop now and completely recover.
"I know I haven`t been 100 percent right since my crash but I was hoping to improve throughout the race. That hasn`t really been the case so I have been putting on a brave face and doing what I can each day."
Gerrans wore the Tour leader`s yellow jersey for two days last year after Orica won the team time-trial.
He had also won the third stage before that, but he has been unable to truly challenge for a stage win this time around.