Holders Real Madrid and city rivals Atletico emerged from Tuesday`s tempestuous 0-0 Champions League quarter-final draw knowing that Real left back Marcelo and Atletico midfielder Mario Suarez are out of next week`s return leg.
At 9 pm local time on Sunday, 98,000 fans at the Camp Nou Stadium here and a worldwide television audience of around one billion will watch what has become the most important club game in the world as FC Barcelona entertain arch-rivals Real Madrid in a game which has become known as 'El Clasico'.
Two-goal Cristiano Ronaldo may have become the record scorer in European competition on Tuesday but the Real Madrid forward was left seething by another poor performance from the stuttering European champions.
Schalke 04 coach Roberto Di Matteo was finding it hard to take in how his team managed to score four goals at Real Madrid on Tuesday but still failed to get past the holders into the Champions League quarter-finals.
Real Madrid boss Carlo Ancelotti admitted he is at a loss to explain the European champions dramatic slump in form as they sneaked into the quarter-finals of the Champions League despite losing 4-3 to Schalke on Tuesday.
European champions Real Madrid will expect to take another step closer to becoming the first team in 25 years to retain the Champions League when they host Schalke on Tuesday holding a 2-0 lead from the first leg of their last 16 tie.
Real Madrid remained on top of the Spanish Primera Liga after coming back from a goal down to defeat Real Sociedad 4-1 while rivals Atletico stayed in touch with the football league leaders with a 3-1 win over Eibar.
The season is only half-way but Real Madrid have already notched up 100-goal mark. Helping Los Blancos achieve the milestone are their famed BBC trio of (Gerath) Bale, (Karim) Benzema and Cristiano (Ronaldo).