After facing a match point during her third-round battle against Zhang Shuai on Saturday, Pliskova was never pushed by Brady, who failed to find her groove on a sunny day that cast a severe shadow across center court.
But with every round unfolding, one or the other chipped off the race. Second-seeded Simona Halep was stunned in the first round of the tournament by Maria Sharapova. Pliskova, Muguruza, and Svitolina raced away deeper into the tournament which put aside the remainders on the list. Ergo, the race now stands between these three tennis players.
Paes and Raja went down 4-6, 6-7(7) on Court 10 of Flushing Meadows in an hour and 27 minutes.
Sharapova, who returned to the tour in April after her suspension ended, had defeated world number two Simona Halep in the first round and was being spoken about as a potential title contender.
The 22nd seed Fognini was cited for three code violations during his 6-4 7-6(8) 3-6 6-0 loss to fellow Italian Stefano Travaglia on Wednesday and was heard directing vulgar language towards Swedish chair umpire Louise Engzell.
Qualifier Shapovalov, 18, was beaten 7-6, (7/2), 7-6 (7/4), 7-6 (7/3) by 26-year-old Carreno Busta, who also made the French Open quarter-finals this year.
Jelena gave birth on Saturday evening and their second child will be named Tara, Blic newspaper reported on its online edition.
Sania and her mixed doubles partner Ivan Dodig of Croatia lost to the Latvian-French pair of Jelena Ostapenko and Fabrice Martin 7-5, 3-6, 6-10.
Chasing a sixth U.S. Open title, Federer needed just one hour and 46 minutes under a closed roof at Arthur Ashe Stadium to put away the 31st seed Lopez.
Nadal will face Ukraine's Alexandr Dolgopolov, against whom he is 6-2, for a place in the quarter-finals.
Currently Sania is in New York where she is competing in the last Grand Slam of the year – US Open.
The 30-year-old Fognini lashed out at the umpire with a series of insults during his first round loss in singles to fellow Italian Stefano Travaglia.
Pliskova, runner-up at Flushing Meadows last year, would have lost her world number one ranking had she been beaten on Arthur Ashe Stadium but moved another step closer to a first career grand slam title.
Soon after Wozniacki attacked Sharapova over the ‘Centre Court’ scheduling for the Russian star at the ongoing US Open, the latter has come hard at the Danish player, taking a swipe at her being knocked out early in the tournament. While Sharapova has entered the fourth round in New York, Wozniacki was knocked out in the second round.
On Day 5 of the US Open on Friday, four Indian players played in the men’s doubles. There was also one representation in the mixed doubles section.