Painkillers without side effects found by researchers

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New Delhi: Researchers from Charite - Universitatsmedizin Berlin have discovered a new way of developing painkillers.This research has been published the journal Science.

The team of researchers used computational simulation to analyze interactions at opioid receptors - the cell`s docking sites for painkillers. When used in an animal model, their prototype of a morphine-like molecule was able to produce substantial pain relief in inflamed tissues.

However, healthy tissues remained unaffected, suggesting that the severe side effects currently associated with these types of painkillers might be avoided.

Opioids are a class of strong pain killers. They are mainly used to treat pain associated with tissue damage and inflammation, such as that caused by surgery, nerve damage, arthritis or cancer.

Common side effects associated with their use include drowsiness, nausea, constipation and dependency and, in some cases, respiratory arrest.

By analyzing drug-opioid receptor interactions in damaged tissues, as opposed to healthy tissues, we were hoping to provide useful information for the design of new painkillers without harmful side effects," explains Prof. Dr. Christoph Stein, Head of the Department of Anesthesiology and Surgical Critical Care Medicine on Campus Benjamin Franklin.

In cooperation with PD Dr. Marcus Weber from the Zuse Institute Berlin, and with the help of innovative computational simulations, the researchers were able to analyze morphine-like molecules and their interactions with opioid receptors.

They were able to successfully identify a new mechanism of action, which is capable of producing pain relief only in the desired target tissues - those affected by inflammation.

Treating postoperative and chronic inflammatory pain should now be possible without causing side effects.

(With Agency inputs)