This new blood test predicts prostate cancer more accurate than PSA

Researchers have demonstrated that a new blood test, known as IsoPSA, can detect prostate cancer more accurately than current tests in two crucial measures.

Image for representational purpose only

New Delhi: Researchers from Cleveland Clinic, Louis Stokes Cleveland VA Medical Center, Kaiser Permanente Northwest, and other clinical sites have demonstrated that a new blood test, known as IsoPSA, can detect prostate cancer more accurately than current tests in two crucial measures - distinguishing cancer from benign conditions and identifying patients with high-risk disease.

By identifying molecular changes in the prostate specific antigen (PSA) protein, the study suggests that once validated, use of IsoPSA may substantially reduce the need for biopsy, and may thus lower the likelihood of overdetection and overtreatment of non-lethal prostate cancer.

The study, led by Eric Klein, conducted a multicentre prospective study of 261 men scheduled for prostate biopsy at five academic and community centres in the US enrolled between August 2015 and December 2016.

Klein said,“Despite criticism, PSA has transformed the landscape of early detection, screening, and management of prostate cancer in the last few decades.”

He added, “Unfortunately, PSA is tissue-specific but not cancer-specific, leading to overdiagnosis and overtreatment of biologically insignificant cancers, which is widely recognized as a key limitation in its clinical utility.”

The findings directly compared the clinical performance of a new test based on PSA, called IsoPSA, to PSA itself with patients already scheduled for prostate biopsy. IsoPSA proved significantly superior to PSA in two key indications: discriminating between prostate cancer and benign conditions; and identifying patients with high-grade disease. The former indication is potentially useful for using IsoPSA for screening by primary care physicians, while the second is helpful for urologists in identifying patients who would benefit from curative intent therapy and other applications.

The results show that if validated and adopted clinically, IsoPSA could significantly reduce the rate of unnecessary biopsies by almost 50 percent.

Dr Klein said,“The methodology used in the IsoPSA assay represents a significant departure from conventional ways to define biomarkers in blood, and may be applicable to improving other cancer biomarkers.”

The study is published online in European Urology.

(With ANI inputs)