Barcelona coach Luis Enrique has left Lionel Messi out of his squad for the European champions` Copa del Rey clash against minnows Villanovense on Wednesday.

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The holders need a win at the Camp Nou to progress to the last 16 after an under-strength Barca side was held 0-0 in the first leg by third-tier Villanovense five weeks ago.

Gerard Pique, Sergio Busquets, Ivan Rakitic and Jordi Alba are also handed a rest.

However, Luis Suarez, Neymar and Andres Iniesta have been included after missing the first leg.