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Controversial World Heavyweight champion Tyson Fury retires
A previously scheduled rematch with Klitschko, set for July 9, was scrapped after Fury sustained an ankle injury.
London: World heavyweight champion Tyson Fury announced he was retiring from boxing in a profanity-laced tweet on Monday.
"Boxing is the saddest thing I ever took part in, all a pile of shit, I`m the greatest, & I`m also retired... " Fury tweeted.
Reports by US broadcaster ESPN last week claimed Fury had tested positive for cocaine and the British fighter had recently cancelled an October bout with Wladimir Klitschko to defend his WBA and WBO heavyweight belts.
The 28-year-old had been scheduled to earn the biggest purse of his career in a rematch with Klitschko at the Manchester Arena after shocking the Ukrainian last November to become world champion.
However, Fury withdrew from that date as his camp claimed he had been "declared mentally unfit to fight".
ESPN reported Fury tested positive after providing a urine sample to Las Vegas-based Voluntary Anti-Doping Association (VADA) in Lancaster, England on September 22.
Cocaine, while an illegal drug, is not banned in boxing if taken out of competition.
Fury appeared to make light of the reports in a Twitter post on Saturday.
He tweeted a picture of Tony Montana, played by Al Pacino in the film Scarface, sitting at a table with a pile of cocaine in front of him.
Fury imposed his own face onto the picture, which he captioned "#Tysonmontana".
Fury, the self-styled `Gypsy King`, also won the IBF belt in his first fight against Klitschko, but had to forfeit it after failing to fulfil a mandatory bout.
A previously scheduled rematch with Klitschko, set for July 9, was scrapped after Fury sustained an ankle injury.
Following the cancellation of that fight, it emerged that UK Anti-Doping (UKAD) had charged Fury and his cousin, Hughie, with a doping offence. They deny wrongdoing.
The sample, taken nine months prior to Fury`s sensational victory over Klitschko, contained traces of the banned substance nandrolone.
Fury was provisionally suspended, but his ban has since been lifted and his legal team have threatened legal action against UKAD.
He is due to face a hearing in November and could have been stripped of his titles if found guilty.
Fury has courted almost constant controversy since winning the world title and he angered many with a series of highly sexist and homophobic comments.