Diabetes and weight: Deficits in the body`s insulin production contribute to being overweight. Poor nutrition, too little movement and too many pounds on the scale influences the risk of metabolic diseases like diabetes. But the relationship works the other way around as well, as a research group led by Dr Daniel Zeman-Meier of the university`s Department of Biomedicine and the University Hospital of Basel reports. 


COMMERCIAL BREAK
SCROLL TO CONTINUE READING

If insulin production is compromised, as is the case in the early stages of type 2 diabetes, this can contribute to being overweight. The researchers report their findings in the journal Nature Communications. The research team focused on protease PC1/3, a key enzyme in the body that transforms various inactive hormone precursors into the final, active forms. If this enzyme isn`t functioning properly in a person, the result can be severe endocrine disorders. 


The consequences include a feeling of uncontrollable hunger and severe overweight. "Until now, it was assumed that this dysregulation is caused by a lack of activation of satiety hormones," explains the study`s leader, Dr Zeman-Meier. "But when we turned off PC1/3 in the brains of mice, the animals` body weight did not change significantly. 


 


Also Read: 7 Tips to lose weight effectively in addition to diet and exercise in 2023


"The researchers concluded from this that something other than a brain malfunction must be responsible. In their next step, they tested whether being overweight could be caused by incorrect activation of other hormones. PC1/3 activates insulin, among other things. Insulin plays a key role in the regulation of blood sugar and fat metabolism. 


"Investigating the role of insulin production as a cause of overweight was obvious," says Dr Zeman-Meier. The researchers shut off PC1/3 specifically in the insulin-producing beta cells of the pancreas in mice. The animals consumed significantly more calories and soon became overweight and diabetic. 


 


Also Read: Want a happy healthy New year: Try these 5 healthy diets for weight loss


"These results are also interesting because PC1/3 is reduced in the pancreas of patients with prediabetes," says Professor Marc Donath, the research group leader and final author of the study. This indicates that incorrect insulin activation could be not only a consequence but also a cause of being overweight.