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New device to make glucose monitoring 'painless' for diabetics

CGMS are uncomfortable since they require a 7mm needle inserted into the skin and still can't reach the most ideal location.

New device to make glucose monitoring 'painless' for diabetics
Representational image

London: Researchers have designed a microneedle patch for people with diabetes to enable them to monitor their glucose levels throughout the day in a "painless" manner. Continuous monitoring is a way to safely and reliably lower blood glucose - giving the user a full picture of their glucose levels throughout the day and helping them avoid severe hypoglycemia.

But the currently used continuous glucose monitoring systems (known as CGMS) are uncomfortable since they require a minimum 7mm needle inserted into the skin. Owing to their size, they take measurements in the fat tissue - not the most ideal location. However, the new device, developed by researchers at KTH Royal Institute of Technology in Sweden, is 50 times smaller.

When applied to a human participant's forearm, the combination of the patch and an extremely miniaturized three-electrode enzymatic sensor was found capable of correctly and dynamically tracking blood glucose levels over time, with a delay of about 10 minutes.

"Our solution is painless to the user. We measure directly in the skin, and there are no nerve receptors that detect pain - just a fine mesh of very tiny blood vessels," Federico Ribe, a doctoral student at the institute, said. Unlike commercially available CGMS which measure the subcutaneous fat tissue, the new device measures within the skin less than 1mm deep, Ribet said.

This would offer an alternative to pricking one's fingers several times a day to take a blood test and the frequency of finger prick tests could be reduced with a glucose monitoring system, he noted. The team has successfully tested the prototype of a microneedle patch on a human participant and the completion of a system for clinical tests is now underway.