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Moores Cancer Center
Moores Cancer Center News
Cancer
03 Oct 2020
Personalised cancer therapy improves outcomes in advanced disease, says study
Led by Razelle Kurzrock, MD, director of the Center for Personalised Cancer Therapy at Moores Cancer Center and senior author of the study, a multidisciplinary molecular tumour board was established to advise treating physicians on the course of care using an individual patient`s molecular tumour makeup to design precision medicine strategies. "Patients who underwent a molecular tumour board-recommended therapy were better matched to genomic alterations in their cancer and had improved outcomes," said Kurzrock. Of 429 patients evaluated by the molecular tumour board, 62 per cent were matched to at least one drug, report the researchers. Twenty per cent of patients matched to all recommended drugs, including combination therapies. The tumour board acted in an advisory role and treating physicians chose not to use the board`s recommended strategy in 38 per cent of cases, opting instead for a standard therapy approach that might have been unmatched to the patient`s genetic alterations or had a low degree of matching. These patients experienced lower progression-free survival and overall survival rates.
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