Ozone Pollution Related With Increased Hospitalizations For Heart Attack: Study

The study reveals that worsening ozone pollution with climate change and the rapid ageing of the global population may produce even greater risks of cardiovascular disease in the future.

Heart attack

The European Heart Journal, a publication of the European Society of Cardiology, published the first evidence that exceeding the World Health Organization (WHO) ozone limit is related to significant increases in hospital admissions for heart attack, heart failure, and stroke (ESC). Even ozone levels lower than the WHO maximum were related to ill health. "During this three-year study, ozone was responsible for an increasing proportion of admissions for cardiovascular disease as time progressed," said study author Professor Shaowei Wu of Xi`an Jiaotong University, China. 

"It is believed that climate change, by creating atmospheric conditions favouring ozone formation, will continue to raise concentrations in many parts of the world. Our results indicate that older people are particularly vulnerable to the adverse cardiovascular effects of ozone, meaning that worsening ozone pollution with climate change and the rapid ageing of the global population may produce even greater risks of cardiovascular disease in the future." 

Ozone is a gas and the main air pollutant in photochemical smog. Ozone pollution is different from the ozone layer, which absorbs most of the sun's ultraviolet radiation. Ozone pollution is formed when other pollutants react in the presence of sunlight. These other pollutants are volatile organic compounds and nitrogen oxides which are emitted by motor vehicles, power plants, industrial boilers, refineries, chemical plants, and biomass and fossil fuel burning facilities. 

Previous studies have suggested that ozone pollution harms the heart and blood vessels, but there is limited and inconclusive evidence about its influence on the risk of cardiovascular disease. This study examined the association between ambient ozone pollution and hospital admissions for cardiovascular disease. 

Data on daily hospital admissions for cardiovascular disease from 2015 to 2017 in 70 cities in China were collected from the two main national health insurance systems. During the study period, the two databases covered approximately 258 million people across 70 cities, equivalent to more than 18 percent of China's population. The types of cardiovascular disease included coronary heart disease, stroke, and heart failure, plus subtypes such as angina, acute myocardial infarction, acute coronary syndrome, ischaemic stroke, and haemorrhagic stroke. 

Daily eight-hour maximum average concentrations of ozone, fine particulate matter (PM2.5), inhalable particles (PM10), sulfur dioxide, nitrogen dioxide, and carbon monoxide were obtained for each city from the China National Urban Air Quality Real-time Publishing Platform. During the study period, there were 6,444,441 hospital admissions for cardiovascular disease in the 70 cities and the average daily eight-hour maximum ozone concentration was 79.2 mg/m3.

Exposure to ambient ozone was associated with increased hospital admissions for all cardiovascular diseases studied except haemorrhagic stroke, independent of other air pollutants. For example, each 10 mg/m3 rise in the two-day average eight-hour maximum ozone concentration was associated with a 0.40 percent increase in hospital admissions for stroke and 0.75 percent for acute myocardial infarction. 

Professor Wu said: "Although these increments look modest, it should be noted that ozone levels may surge to higher than 200 mg/m3 in summer, and these increases in hospitalizations would be amplified by more than 20 times to over 8 percent for stroke and 15 percent for acute myocardial infarction." 

The researchers also estimated the excessive admission risk for cardiovascular disease associated with ozone concentrations at or above the WHO air quality guideline (100 ug/m3) compared to levels below 70 mg/m3. Ozone levels below 70 mg/m3 are mostly naturally occurring and not due to human activity. 

Compared to two-day average eight-hour maximum concentrations below 70 mg/m3, levels of 100 ug/m3 or higher were associated with substantial increases in hospital admissions for cardiovascular disease, ranging from 3.38 percent for stroke to 6.52 percent for acute myocardial infarction. Nevertheless, lower concentrations of 70 to 99 ug/m3 (vs. below 70 mg/m3) were also linked with increases in hospital admissions, ranging from 2.26 percent for heart failure to 3.21 percent for coronary heart disease. 

From 2015 to 2017, 3.42 percent, 3.74 percent, and 3.02 percent of hospitalisations for coronary heart disease, heart failure, and stroke, respectively, were attributable to ozone pollution. When each year was analysed separately, the proportions rose with time. For coronary heart disease, ozone was responsible for 109,400 of 3,194,577 admissions over three years. 

Professor Wu said: "This suggests that 109,400 coronary heart disease admissions could have been avoided if ozone concentrations were 0 ug/m3. This may be impossible to achieve given the presence of ozone from natural sources. However, we can conclude that considerable numbers of hospital admissions for cardiovascular disease could be avoided if levels were below 100 mg/m3, with further reductions at lower concentrations." 

In an accompanying editorial, Professor Thomas Munzel and co-authors said: "Projections for Europe suggest that ozone will play a more dominant role as a health risk factor in the future due to climate change with rising temperature and, accordingly, increasing photochemical formation of ozone. The strong link between climate change and air quality means that reducing emissions in the long term to tackle global warming will play a key role in alleviating ozone pollution and improving the air that we breathe."