Genes `control brain functions`

The study provides the first evidence of a genetic effect on how ‘cost-efficient’ our brain network wiring is.

Updated: Mar 04, 2011, 14:13 PM IST

Washington: A new study, led by University of Melbourne, has shown that how well our brain functions is largely based on our family’s genetic makeup.

The study provides the first evidence of a genetic effect on how ‘cost-efficient’ our brain network wiring is, shedding light on some of the brain’s make up.

Lead author Dr Alex Fornito from the Melbourne Neuropsychiatry Centre at the University of Melbourne said the findings have important implications for understanding why some people are better able to perform certain tasks than others and the genetic basis of mental illnesses and some neurological diseases.

“The brain tries to maximize its bang-for-buck by striking a balance between making more connections to promote efficient communication and minimising the “cost” or amount of wiring required to make these connections. Our findings indicate that this balance, called ‘cost-efficiency’, has a strong genetic basis.”

“Ultimately, this research may help us uncover which specific genes are important in explaining differences in cognitive abilities, risk for mental illness and neurological diseases such as schizophrenia and Alzheimer’s disease, leading to new gene-based therapies for these disorders.”

“Although genes play a major role in brain function, the environment and other factors contribute to when things go wrong in cases of mental illness and other brain disorders,” he said.

The research team, which included scientists at the Universities of Queensland and Cambridge, UK compared the brain scans of 38 identical and 26 non-identical twins from the Australian Twin Registry.

Using new techniques, the researchers were able to construct detailed maps of each person’s brain network and measured the cost-efficiency of network connections for the entire brain, as well as for specific brain regions.

“We found that people differed greatly in terms of how cost-efficient the functioning of their brain networks were, and that over half of these differences could be explained by genes,” said Fornito.

Across the entire brain, more than half (60%) of the differences between people could be explained by genes. Some of the strongest effects were observed for regions of the prefrontal cortex which play a vital role in planning, strategic thinking, decision-making and memory.

The study has been published in the international publication The Journal of Neuroscience.

ANI