Nose is gateway for virus
Washington: It`s believed that humans have 14 types of noses. But whatever the type you have, the vital organ of your face is a gateway for virus linked to brain disorders, scientists have claimed.
Researchers in the US found that the nose can be a portal for herpes virus-6 (HHV-6), a member of herpes viruses family, which is linked to brain disorders such as multiple sclerosis, encephalitis and a form of epilepsy.
It also causes roseola, a disease common among infants that leads to high fever and skin rash, LiveScience reported.
"This is a virus that we`ve all been exposed to, that we all pretty much acquired in childhood," said researcher Steven Jacobson, a neurovirologist at the National Institute of
Neurological Disorders and Stroke in Bethesda, Maryland. "Most of the time it`s utterly benign."
The way this virus entered the brain had remained a mystery, as the seat of our intelligence is largely protected by the so-called blood-brain barrier, which filters out many germs and drugs.
However, researchers had known that other viruses, such as influenza and rabies, apparently could use the sensory network hooked up to the nose as a kind of highway into the central nervous system.
To see how HHV-6 enters the brain, scientists analysed tissue samples from autopsies, including a patient who had multiple sclerosis. Although viral DNA was seen throughout the brain, it was found largely in the olfactory bulb, the brain region involved in detecting odours.
In addition, the researchers found DNA from HHV-6 in nasal mucus samples from healthy people, those suffering a loss of smell, and people with multiple sclerosis.
This suggests the nasal cavity might harbour the virus in both healthy and diseased individuals, the team reported in the Proceedings of the National Academy of Sciences.
Moreover, in experiments, the scientists demonstrated that HHV-6 could infect lab-grown versions of the olfactory ensheathing cells, which help olfactory neurons grow and establish connections in the brain.
The researchers believe the virus might use these cells as a bridge across the blood-brain barrier, the first time scientists had evidence these cells could be a route of infection.
"Now researchers can start looking to see if other viruses might use this route as well," Jacobson said.
The researchers cautioned that while this virus might help trigger brain disorders, it was not necessarily the primary cause. "We may all have it, but some might have a special genetic susceptibility to it, or maybe there`s an environmental trigger that causes neurologic disease to then occur," Jacobson said.
Further studies could also investigate whether this virus has any effect on behaviour. "It all depends on where this virus goes in the brain," Jacobson said.
With the new information, researchers could then look for therapies against this virus.
More from India
More from World
More from Sports
More from Entertaiment
- Zee Media exclusive chat with 'Welcome to Karachi' cast
- Manali: Heavy corruption found in environmental taxes
- UP Minister allegedly threatens, abuses Gonda businessman
- UP: Jammu-bound Muri Express derails in Kaushambi
- Five unmanned parachute-like objects spotted over Mumbai airport
- Aapke Sitare: Astro prediction for May 24, 2015
- Watch: Fast N Facts @ 7:30pm
- CBSE Board Class 12th Exam Results 2015 declared
- Dawood's intercepted phone calls prove yet again he is in Pakistan
- Jaipur girl Mini Rajpal wins Miss India Deaf 2015!
- One year of Modi govt: How satisfied is the common man?
- Mumbai architecture creates double decker bus from scrap!
- Delhi's 2015 CBSE Class 12 topper M Gayatri talks to Zee Media
- One year of Modi govt: How satisfied is the common man? Part-2
- One year of Modi govt: PM addresses mega rally in Mathura
- IPL 2015 Final: MI vs CSK - As it happened...
- CBSE.nic.in 12th XII Results 2015: CBSE Board (cbseresults.nic.in) Class 12th XII Exam Results 2015 to be announced on May 25
- Heatwave claims over 550 lives so far, Delhi saw hottest day
- IPL 2015 final: Mumbai Indians thrash Chennai Super Kings by 41 runs to lift second title
- LIVE - Cbse.nic.in & cbseresults.nic.in Class 12th XII Results 2015: CBSE Board Class 12th XII Exam Results 2015 to be announced shortly
- Cbse.nic.in & cbseresults.nic.in Class 12th XII Results 2015: CBSE Board Class 12th XII Exam Results 2015 declared
- Check cbseresults.nic.in for CBSE Class 12 result 2015
- Two dead, over 100 injured as Muri Express derails in UP; Prabhu announces Rs 2 lakhs ex-gratia for kin of dead
- Mathura rally: PM Modi slams 'corrupt' UPA regime, lauds NDA govt's efforts in past one year
- CBSE Class 12 results out: Here's how you can check
- PM Narendra Modi's Mathura rally: As it happened
- Check WBBSE (wbresults.nic.in) Class 12th Results: West Bengal Board (wbscvet.org) Higher Secondary Class XII Vocational Results to be declared today at 4 PM
- Public rally on 100 days of AAP govt: As it happened
- CBSE Board 12th XII Results 2015: Cbse.nic.in & cbseresults.nic.in Class 12th XII Exam Results 2015 to be announced today at 12 Noon
- CBSE XII Results 2015: 12th board exam results to be declared tomorrow