London: Scientists have identified a tumour-suppressing gene called DCC gene (Deleted Colorectal Cancer), which protects against the onset of cancer by causing the death of cells that become cancerous.The research team at Lyon has also developed an animal model carrying a mutation of the DCC gene. Mice carrying the mutation develop tumours, because this gene can no longer induce the death of the cancer cells.This discovery could lead to the development of a new targeted cancer treatment that aims to reactivate the dying of cancer cells.The team led by Patrick Mehlen, Director of the DEVweCAN ‘Laboratory of Excellence’ at the Lyon Cancer Research Centre (CNRS/Inserm/Centre Leon Berard/Universite Claude Bernard 1), studies the cell death process (apoptosis) and, in particular, the mechanism that makes the cells understand that they should initiate a self-destruction process when they become abnormal.
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