Washington: In a new study, researchers at Washington University School of Medicine in St. Louis have discovered why breast cancer patients with dense breasts are more likely than others to develop aggressive tumours that spread. The finding opens the door to drug treatments that prevent metastasis.It has long been known that women with denser breasts are at higher risk for breast cancer. This greater density is caused by an excess of a structural protein called collagen. "We have shown how increased collagen in the breasts could increase the chances of breast tumours spreading and becoming more invasive," said Gregory D. Longmore, MD, professor of medicine. "It doesn`t explain why women with dense breasts get cancer in the first place. But once they do, the pathway that we describe is relevant in causing their cancers to be more aggressive and more likely to spread," he stated.
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