Paris: Everton, the lone British representative remaining in the Europa League, were given a testing last-16 tie against Ukrainian outfit Dynamo Kiev after the draw was made on Friday in Switzerland.
Roberto Martinez`s side have not reached the later stages of a European competition since they won the 1985 Cup Winners` Cup, but will have to earn a result in war-torn Ukraine to reach the quarter-finals.
Fiorentina host Roma, in the first leg of their all-Italian tie, while holders Sevilla will be on the road at Villareal on March 12 for the first match in a battle of La Liga hopefuls.
Another attractive tie features three-time winners Inter Milan at Wolfsburg in the first matchup between the Serie A giants and second-placed Bundesliga side.
Napoli, who were inspired to UEFA Cup victory by Diego Maradona in 1989, host Dinamo Moscow while the fifth Italian team in the draw, Torino, travel to Russia and a first-leg matchup against 2008 winners Zenit St. Petersburg.
Ajax, the only domestic champions in the last-16 and 1992 winners, also travel to the Ukraine and a difficult test against Dnipro Dnipropetrovsk.
Ukrainian and Russian teams were kept apart following a UEFA decision over the unrest between the two neighbors.
Finally, Belgian outfit Club Brugge host Turkish club Besiktas.
Everton (ENG) v Dynamo Kiev (UKR)
Dnipro Dnipropetrovsk (UKR) v Ajax (NED)
Zenit St. Petersburg (RUS) v Torino (ITA)
VfL Wolfsburg (GER) v Inter Milan (ITA)
Villarreal (ESP) v Sevilla (ESP)
Napoli (ITA) v Dinamo Moscow (RUS)
Club Brugge (BEL) v Besiktas (TUR)
Fiorentina (ITA) v Roma (ITA)
The first legs will be played on March 12 with the return fixtures on March 19 and the final set to be staged at Warsaw on May 27.