The blaze was noticed around 12 noon on the fourth floor of the main building, said an official of BMC Disaster Control Room.
Since Saturday is also a weekend holiday, there were no staffers in the building.
According to preliminary information, a suspected short-circuit could have caused the conflagration.
Seven fire tenders were rushed to tackle the blaze, which was brought under control a short time later.
This is the second fire in Mantralaya in the past 10 months. Last year, June 21, a major fire gutted large parts of the building killing at least five persons, including some government staffers.
After that incident, the building has been undergoing major repairs and renovation works.
Mumbai: A fire broke out in Mantralaya, the state government headquarters at Nariman Point here Saturday afternoon, officials said.
First Published: Saturday, March 09, 2013, 13:19