Washington: Ageing in the central nervous system for multiple sclerosis (MS) patients may be reversed, a new study suggested.In multiple sclerosis, the insulating layers that protect nerve fibres in the brain, known as myelin sheaths, become damaged. The loss of myelin in the brain prevents nerve fibres from sending signals properly and will eventually lead to the loss of the nerve fibre itself.However, early in the disease, a regenerative process, or remyelination, occurs and the myelin sheaths are restored. Unfortunately, as people with MS age, remyelination decreases significantly, resulting in more nerve fibres being permanently lost.However, the latest study in mice shows that the age-associated decline in the regeneration of the nerve’s myelin sheath, or remyelination, is reversible.The proof of principle study demonstrates that when old mice are exposed to the inflammatory cells (called monocytes) from young mice, the ageing remyelination process can be reversed.
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