Washington: A study has found that Manuka honey could help in clearing chronically infected wounds, and even in reversing bacterial resistance to antibiotics.
Cooper``s group is helping to solve this problem by investigating at a molecular level the ways in which manuka honey inhibits wound-infecting bacteria. "Our findings with streptococci and pseudomonads suggest that manuka honey can hamper the attachment of bacteria to tissues which is an essential step in the initiation of acute infections," she explained. "Inhibiting attachment also blocks the formation of biofilms, which can protect bacteria from antibiotics and allow them to cause persistent infections. "Other work in our lab has shown that honey can make MRSA more sensitive to antibiotics such as oxacillin - effectively reversing antibiotic resistance. "This indicates that existing antibiotics may be more effective against drug-resistant infections if used in combination with manuka honey," she revealed.This research may increase the clinical use of manuka honey as doctors are faced with the threat of diminishingly effective antimicrobial options. "We need innovative and effective ways of controlling wound infections that are unlikely to contribute to increased antimicrobial resistance. We have already demonstrated that manuka honey is not likely to select for honey-resistant bacteria," Cooper said. At present, most antimicrobial interventions for patients are with systemic antibiotics. "The use of a topical agent to eradicate bacteria from wounds is potentially cheaper and may well improve antibiotic therapy in the future. This will help reduce the transmission of antibiotic-resistant bacteria from colonised wounds to susceptible patients," she concluded.The research was presented at the Society for General Microbiology``s Spring Conference in Harrogate. ANI
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