Washington: The deadly plaques of Alzheimer`s disease interact with certain cellular proteins to inhibit normal signals that maintain blood flow to the brain, a researcher at the University of Pittsburgh School of Medicine has discovered. Levels of nitric oxide (NO) – a signaling molecule that helps regulate blood flow, immune and neurological processes – are known to be low in the brains of people who have Alzheimer`s disease, but the reason for that hasn`t been clear, said study co-author Jeffrey S. Isenberg, associate professor, Division of Pulmonary, Allergy, and Critical Care Medicine, Pitt School of Medicine.
"It`s possible that an agent that could block either CD36 or CD47 could slow the progress of neuronal degeneration in Alzheimer`s by protecting the production of NO in the brain," Isenberg said. "Importantly, we have already indentified therapeutic agents that can interrupt the inhibitory signal induced by these interactions to maximize NO production, signaling and sensitivity." The findings have been published in Public Library of Science One. (ANI)
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