Lou Gehrig`s disease`s mechanism identified
Washington: Researchers have linked the toxic build-up of certain proteins and related molecules in cells, including neurons, to mutations in a gene that causes amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders.
St. Jude Children`s Research Hospital scientists` new findings have provided the first evidence that a gene named VCP plays a role in the break-up and clearance of protein and RNA molecules that accumulate in temporary structures called RNA granules.
RNAs perform a variety of vital cell functions, including protein production. RNA granules support proper functioning of RNA.
In ALS and related degenerative diseases, the process of assembling and clearing RNA granules is impaired. The proteins and RNAs associated with the granules often build up in nerve cells of patients. This study shows how mutations in VCP might contribute to that process and neurodegenerative disease.
Roy Parker, Ph.D., of the University of Colorado`s Department of Chemistry and Biochemistry and the Howard Hughes Medical Institute (HHMI), said that a strength of this study is that it provides a unifying hypothesis about how different genetic mutations all affect stress granules, which suggests that understanding stress granule dynamics and how they can be manipulated might be beneficial for treatment of these diseases.
Regina-Maria Kolaitis, Ph.D., a postdoctoral fellow in Taylor`s laboratory said that the research also tiesVCP mutations to disruption of RNA regulation, which prior studies have connected to the progression of neurodegenerative diseases.
For this study, researchers used yeast to identify a network of 125 genes that affect the formation and behaviour of stress granules. One of the genes that appeared to play a central role in the network was CDC48, which functions like VCP in yeast. In addition, many of the genes identified are involved in a process called autophagy that cells use to break down and recycle unneeded molecules, including proteins.
Working in yeast and mammalian cells, researchers showed that stress granules are cleared by autophagy, which stalled when VCP was mutated. Researchers also reported that stress granules accumulated following mutation of either CDC48 or VCP.
The research has been published in the scientific journal Cell.
Download the all new Zee News app for Android and iOS to stay up to date with latest headlines and news stories in Politics, Entertainment, Sports, Technology, Business and much more from India and around the world.
More from India
More from World
More from Sports
More from Entertaiment
- DNA: Exiled Kashmiri Pandits share their heart wrenching stories
- Basic ideals of Constitution are in danger: Sonia Gandhi
- PM Modi greets nation on occasion of first Constitution Day
- Manjula Vaghela's journey: From rag picker to head of a firm with Rs 1 cr turnover!
- Indian Army faces shortage of field firing ranges in J&K
- Woman commits suicide after heated discussion with husband over Aamir Khan's intolerance remark
- Eat smart to slow down ageing and increase longevity!
- Intolerance issue: Those attacking me are only proving my point, says Aamir Khan – Read full statement
- Setback to Kejriwal-led AAP as MLA Akhilesh Tripathi arrested in riot case
- 10 interesting facts about Constitution which every Indian must know