London: Researchers from Cincinnati Children’s Hospital Medical Center have identified the key culprit behind severe asthma-like symptoms in mice.The disease can be triggered in susceptible people by a variety of environmental contaminants – such as cigarette smoke, allergens and airborne pollution.Dr. Marsha Wills-Karp and her colleagues have identified the pro-inflammatory protein, interleukin-17 (IL-17A), as the molecular tipping point that upsets a delicate balance between underlying mild disease and more severe asthma, reports Nature.
As the team continues their research, they will study the relationship between C3 and IL-17A in severe asthmatics, and explore the effectiveness of targeting either the C3 or IL-17A pathways for the treatment of severe asthma.The study is published in the latest Nature Immunology. ANI
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