‘Mothers curse’ responsible for male infertility
Melbourne: A new study in fruit flies has found that genetic mutations in mitochondria, inherited from the mother, are an important cause of male infertility.
"What we`ve uncovered here is an evolutionary process that can explain why male infertility is so common," said evolutionary biologist Dr Damian Dowling of Monash University in Melbourne.
"Our study is essentially the first evidence for the ``mothers curse,`` added Dowling.
Dowling and colleagues carried out an experiment to test this "mothers curse" idea.
They gathered mitochondrial DNA from a diverse range of fruit flies around the world and inserted it into flies that had identical nuclear DNA.
They found that the different mitochondrial DNA affected the expression of about a 1000 nuclear genes in males, but had no effect on the same genes in females.
"The maternal transmission of the mitochondrial genome results in a process which we call the sex-specific selective sieve - mutations are getting through the sieve of natural selection," said Dowling.
"The top 300 of these differentially expressed genes are located within the male testes or in the glands that are responsible for producing the ejaculate," said Dowling.
"It basically points firmly at the idea that males harbour this load of mutations within the mitochondria that are all teaming up to effect male fertility in a detrimental way,” added Dowling.
The study has been published in the journal Science.
More from India
More from World
More from Sports
More from Entertaiment
- Highlights - India vs England 2nd ODI in Cuttack
- Missed the dance of American President Donald Trump? - Watch it here
- DNA: Manish Sisodia faces CBI probe over alleged irregularities in 'Talk To AK' programme
- Pawan, a BE student develops smart dustbin -Watch
- Donald Trump to be sworn in as 45th US President today
- WATCH: MS Dhoni asks Jasprit Bumrah to go easy after he hurriedly ran out England skipper Eoin Morgan
- Accused of Muslim-bias on visa applications, Sushma Swaraj hits back
- WATCH: How MS Dhoni saved Yuvraj Singh's wicket with another successful DRS review
- Cuttack ODI: Umpire Kumar Dharmasena messes up DRS review, twitter couldn't stop trolling
- India vs England: After Virender Sehwag, Sachin Tendulkar gives Piers Morgan cricketing gyan