BPA exposure during pregnancy ups asthma risk in kids

Last Updated: Saturday, March 2, 2013 - 13:18

Washington: Early childhood exposure to the chemical bisphenol A (BPA) can elevate risk for asthma in young children, a new study has revealed.

Researchers at the Columbia Center for Children`s Environmental Health at the Mailman School of Public Health are the first to report the association.

BPA is a component of some plastics and is found in food can liners and store receipts.

"Asthma prevalence has increased dramatically over the past 30 years, which suggests that some as-yet-undiscovered environmental exposures may be implicated. Our study indicates that one such exposure may be BPA," lead author Kathleen Donohue, MD, an assistant professor of Medicine at Columbia University College of Physicians and Surgeons and an investigator at the Center for Children`s Environmental Health said.

Dr. Donohue and her co-investigators followed 568 women enrolled in the Mothers and Newborns study of environmental exposures.

BPA exposure was determined by measuring levels of a BPA metabolite in urine samples taken during the third trimester of pregnancy and in the children at ages 3, 5, and 7.

Physicians diagnosed asthma at ages 5 to 12 based on asthma symptoms, a pulmonary function test, and medical history. A validated questionnaire was used to evaluate wheeze.

After adjusting for secondhand smoke and other factors known to be associated with asthma, the researchers found that post-natal exposure to BPA was associated with increased risk of wheeze and asthma.

BPA exposure during the third trimester of pregnancy was inversely associated with risk of wheeze at age 5.

This unexpected finding is in contrast to the results of a previous study, which found that BPA exposure during the second trimester, a critical period for the development of airways and the immune system, was positively linked with risk for asthma.

Increased risk for wheeze and asthma was seen at "fairly routine, low doses of exposure to BPA," Dr. Donohue said.

"Like most other scientists studying BPA,` we do not see a straightforward linear dose-response relationship," she said.

At all three time points, more than 90 percent of the children in the study had detectable levels of BPA metabolite in their bodies, a finding that is in line with previous research.

This does not mean that they will all develop asthma, Dr. Donohue said.

"Just as smoking increases the risk of lung cancer but not everyone who smokes gets lung cancer, not every child exposed to BPA will develop asthma," she added.

The findings are published in the Journal of Allergy and Clinical Immunology.


First Published: Saturday, March 2, 2013 - 13:18

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