Gene that consistently alters in obese people found
Washington: Scientists have identified a gene that gets consistently altered in obesity.
The gene LY86 was among a group of 100 genes identified as likely contributors to obesity through genome-wide association studies comparing the DNA of thousands of obese and lean individuals, said Dr. Shaoyong Su, genetic epidemiologist at the Medical College of Georgia at Georgia Regents University.
Su looked at progressively larger groups of obese versus lean individuals and found LY86 consistently and highly chemically altered, or methylated, in the obese individuals.
"The association is solid; the methylation of this gene is important in obesity," Su said.
It`s known that obesity is highly inheritable; that if parents are obese, children are at higher risk.
"However environment, including high-fat foods and chemical exposure, can put you at risk as well," Su said.
Previously LY86 had been known as an inflammation gene and Su`s studies show, in fact, that it may be contributing to more than just obesity.
He found high methylation of LY86 also was associated with increased inflammation - a risk factor for a variety of maladies such as heart disease and cancer - as well as insulin resistance, a cause of diabetes.
This association also held up among a group of about 703 subjects that, like the general public, included obese, lean and average-weight individuals.
More from India
More from World
More from Sports
More from Entertaiment
- PM Narendra Modi's speech at Heart of Asia conference
- Like SAARC, should India boycott Pak in Heart of Asia conference?
- India-Afghanistan thrash Pakistan over terrorism issue in Heart of Asia conference
- Tamil Nadu CM Jayalalithaa suffers cardiac arrest; being monitored
- Watch: PM Modi addresses rally in Moradabad, UP - Part II
- Rs 14,000 crore default case: Gujarat businessman detained, says money belongs to politicians, babus
- Fake or Real? 'Alien animal' caught on Karnataka-Kerala border
- Tamil Nadu CM Jayalalithaa's condition continues to remain critical after suffering cardiac arrest
- People want to know whether Jayalalithaa is alive or not; PM Narendra Modi must intervene, says expelled AIADMK MP Sasikala Pushpa
- Jayalalithaa's health condition: Amma critical, nation's political fraternity expresses concern - Who said what