Washington: Scientists have discovered that a faulty genetic pathway could be responsible for a range of allergies.The research by the Johns Hopkins Children`s Center and the Johns Hopkins Institute of Genetic Medicine has found that aberrant signalling by a protein called transforming growth factor-beta, or TGF-beta, may be responsible for disrupting the way immune cells respond to common foods and environmental allergens, leading to a wide range of allergic disorders.It was found that mutations in the genes that lead to abnormal TGF-beta signaling are also keys to Marfan and Loeys-Dietz syndromes, genetic conditions marked by blood vessel laxity and dangerous stretching of the aorta, the body`s largest blood vessel."Disruption in TGF-beta signalling does not simply nudge immune cells to misbehave but appears to singlehandedly unlock the very chain reaction that eventually leads to allergic disease," senior investigator Harry "Hal" Dietz, M.D. said.
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