Washington: Scientists have discovered a new mechanism that helps the brain adapt to stress – the finding may eventually lead to a better understanding of why prolonged and repeated exposure to stress can lead to anxiety disorders and depression.Most stressful stimuli cause the release of corticotropin-releasing hormone (CRH) from neurons in the brain. This is typically followed by rapid changes in CRH gene expression. In more practical terms, as soon as the CRH-containing neurons run out of CRH, they are already receiving directions to make more. CRH controls various reactions to stress, including immediate “fight-or-flight” responses as well as more delayed adaptive responses in the brain.
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