Protein involved in longevity `identified`
Washington: In a major finding which may
have relevance to human biology, scientists have identified a
key protein which is involved in the longevity of roundworms.
A team at Thomas Jefferson University has found that
worms born without this protein, called arrestin, lived about
one-third longer than normal, while worms that had triple the
amount of arrestin lived one-third less.
The research also showed that arrestin interacts with
several other proteins within cells to regulate longevity. The
human version of one of these proteins is PTEN, a well-known
tumor suppressor, the `Biology and Nature` journal reported.
Because most proteins in worms have human
counterparts, these findings may have relevance to human
biology and the understanding of cancer development, said lead
scientist Jeffrey L Benovic.
"The links we have found in worms suggest the same
kind of interactions occur in mammals although human biology
is certainly more complicated. We have much work to do to sort
out these pathways, but that is our goal," said Benovic.
In their research, the scientists used the roundworm
as a model because it offers a simple system to study the
function of genes and proteins that are relevant to human
The worm, for example, has one arrestin gene, whereas
humans have four. Worms only have 302 neurons compared to the
100 billion or so in the human brain. In addition, their short
lifespan of two to three weeks allows for timely observation
of effects on longevity.
The team studied signalling pathways activated by G
protein-coupled receptors. These receptors bind to all kinds
of hormones, sensory stimuli, and neurotransmitters which then
activate a cascade of signals inside the cell.
They regulate many physiological processes and are the
target for about half of the drugs currently on the market.
"When it comes to receptors, worms are actually more
complex. Humans have about 800 different kinds of G protein
-coupled receptors while the worm has about 1,800. It relies
upon these receptors to respond to sensory stimuli as well as
various neurotransmitters and hormones," Benovic said.
More from India
More from World
More from Sports
More from Entertaiment
- I eat beef, can somebody stop me?: Kiren Rijiju hits back at Naqvi
- Delhi: Visually impaired boy scores 91.4% in CBSE 12th Board exams
- MP: 14-year-old boy works as bonded labour since 2009
- UP: Man chops off wife's nose, hair for dowry
- Zee Media Exclusive: The plight of yoga expert Tejaswi Sharma
- Heat ave continues in India, death toll climbs to over 1,400
- Megastar Amitabh Bachchan slapped with Rs 1 crore notice
- Woman denied flat in Mumbai for being a Muslim
- 4 Indians in Forbes' 100 most powerful women list
- Kenyan lawyer offers to marry Barack Obama's daughter Malia
- Gujjar stir: HC asks Rajasthan govt to clear rail track, roads
- Maggi likely to face ban in India!
- Gujjar stir: HC asks Rajasthan govt to clear rail track, roads- Part II
- AIB: The 'Third Gender's right to dignity'
- Salman Khan accident files burnt in Mantralaya fire
- CBSE Class 10 Board Result 2015 to be announced today
- Check mahresult.nic.in for MSBSHSE Maharashtra Class 12 HSC Result 2015
- CBSE Class 10 Board Result 2015 (cbse.nic.in, cbseresults.nic.in) postponed?
- Maharashtra MSBSHSE HSC Result 2015 on mahresult.nic.in
- Check cbse.nic.in, cbseresults.nic.in for CBSE Class 10 Result 2015
- First look: Salman Khan steals thunder in `Bajrangi Bhaijaan`
- I was misquoted, says Kiren Rijiju on 'beef' remark
- CBSE Class 10 (Class X Board) Result 2015 on cbse.nic.in, cbseresults.nic.in at 2 pm
- mahresult.nic.in updated with MSBSHSE Maharashtra HSC Class XII Result 2015
- Manmohan Singh defends himself on 2G charge, slams Modi govt for 'carbon copy' schemes
- Sonia Gandhi 'unconstitutional authority' during UPA: PM Narendra Modi
- Hours after attacking NDA govt, Manmohan Singh meets PM Narendra Modi
- Reservation stir: Five percent job quota to Gujjars unlikely, hints Rajasthan govt
- PMO website revamped, now send e-mail to PM Modi directly
- Check cbseresults.nic.in, cbse.in for CBSE Class 10 X Board Result at 2 pm