Fatty liver disease prevented in mice
Washington: Researchers have discovered a way to prevent nonalcoholic fatty liver disease - the most common cause of chronic liver disease worldwide - in mice.
According to investigators at Washington University School of Medicine in St. Louis, blocking a path that delivers dietary fructose to the liver prevented mice from developing the condition.
First author Brian J. DeBosch, MD, PhD, clinical fellow in pediatric gastroenterology, said that there are competing hypotheses about the origins of metabolic syndrome and one of these hypotheses is that insulin resistance begins to develop in the liver first.
The research team, led by Kelle H. Moley, MD, the James P. Crane Professor of Obstetrics and Gynecology, showed that a molecule called GLUT8 carries large amounts of fructose into liver cells.
In this study, researchers showed that blocking or eliminating GLUT8 in mice reduced the amount of fructose entering the organ and appeared to prevent the development of fatty livers. Mice with GLUT8 deficiency also appeared to burn liver fat at a faster rate than control mice.
The researchers also saw differences between male and female mice in the degree to which they were protected from fatty livers and in whole-body metabolism. Male mice fed a high-fructose diet while deficient in GLUT8 still had evidence of fatty liver disease, but whole-body metabolism was healthy.
They showed no evidence of metabolic syndrome in the rest of the body. Females fed fructose while lacking GLUT8, in contrast, had healthy looking livers but exhibited more evidence of whole-body metabolic syndrome.
The study has been published in The Journal of Biological Chemistry.
More from India
More from World
More from Sports
More from Entertaiment
- One year of Modi govt: PM promises to fulfil aspirations
- Watch: Mumbai cops find new secret agents in housewives!
- Hundreds die as heat wave continues in India
- 2G scam: Ex-TRAI chief alleges Manmohan Singh had warned him to cooperate
- Pranab Mukherjee defends Bofors scam, says it was just a media trial
- Salman Khan attends sister Arpita's wedding reception in Mandi
- Zee Media's mega survey on Modi govt
- Zee Media Exclusive: Vidya Balan chats about 'Hamari Adhuri Kahani'
- Para athlete Deepa Malik complains of callous service by Air India
- I eat beef, can somebody stop me?: Kiren Rijiju hits back at Naqvi
- Smriti Irani visits Amethi, promises to pay insurance money to 25,000 women
- Delhi: Visually impaired boy scores 91.4% in CBSE 12th Board exams
- One year of Modi govt: Amit Shah addresses media
- MP: 14-year-old boy works as bonded labour since 2009
- UP: Man chops off wife's nose, hair for dowry
- One year of NDA govt: PM Modi writes open letter to nation, promises to transform India
- Arpita-Aayush wedding reception: Salman Khan spreads love in Mandi, says `hum aapke hain`
- World optimistic about India: PM Narendra Modi on 1 year of NDA govt
- MSBSHSE Class 12th HSC results 2015 to be declared at 1pm tomorrow
- CBSE Class 10 Board Result 2015 (cbse.nic.in, cbseresults.nic.in) postponed?
- CBSE Class 10 Board Result 2015 to be announced on May 28
- Rahul Gandhi takes a dig at one year of Modi govt, wishes 'happy birthday' to 'suit-boot ki sarkar'
- Bharatiya Janata Party lacks majority for Ram Temple, Article 370: Amit Shah
- Check mahresult.nic.in for MSBSHSE Maharashtra Class 12 HSC Result 2015
- AAP govt moves resolution against MHA notification: As it happened
- Maharashtra MSBSHSE HSC Result 2015 on mahresult.nic.in
- Heatwave kills 90 more in Andhra, Telangana; toll crosses 800
- I was misquoted, says Kiren Rijiju on 'beef' remark
- Gujjars adamant on holding talks in Bayana; rail tracks remain blocked
- CBSE 10th result to be declared tomorrow